2016年6月毕业于上海交通大学医学院细胞生物学专业,获得博士学历。同年九月进入青岛大学医学部必赢线路检测中心任讲师一职,从事教学科研工作。博士期间,主要从事干细胞的免疫与分化机制的研究,熟练掌握了多种动物实验,细胞生物学实验和分子生物学实验的基本操作技能。目前累以第一及通讯作者发表SCI论文9篇,获批国家级及省部级项目5项。
一、主要研究方向
1、呼吸道菌群与空气污染物致肺功能降低的关联研究
2、呼吸道菌群干预的保护作用及机制研究
二、代表性科研成果
1.M Jiang#, Y Yan#, T Wang, B Wang, J Li, Y Liu, Y Li, J Tang, S Leng, Y Zheng* Airway microbiome dysbiosis in populations under chronic long-term exposure to diesel engine exhaust, Particle and Fibre Toxicology, peer review (Q1, IF=10)
2.M Jiang #, Ch Hu#, C Rowe, H Kang, X Gong, C Dagucon, J Wang, Y Lin, A Sood, Y Guo, Y Zhu, N A Gilliland, S Belinsky, X Yu*, S Leng*, Application of artificial intelligence in quantifying lung deposition dose of black carbon in people with exposure to ambient combustion particles, J Expo Sci Environ Epidemiol 2023 Oct 17 (Q3, IF=4.5)
3.H Si, T Gao, J Yang, J Zhu, Y Han, Ch Li, J Wang, J Li, Y Zhao, L Chen, Y Zheng, Jiang M*, Multi-omics reveals hypertrophy of adipose tissue and lipid metabolism disorder via mitochondria in young mice under real-ambient exposure to air pollution, Front Pharmacol, 2023 Mar 23;14:1122615 (Q2, IF=5.6)
4.J Wang, Y Yan, H Si, J Li, Y Zhao, T Gao, J Pi, R Zhang, R Chen, W Chen, Y Zheng, Jiang M*, The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2, Ecotoxicol Environ Saf, 2023 Apr 1;254:114702 (Q2, IF=6.8)
5.Jiang M, Li D, Piao J, Li Y, Chen L, Li J, Yu D, Pi J, Zhang R, Chen R, Chen W, Zheng Y*, Nrf2 modulated the restriction of lung function via impairment of intrinsic autophagy upon real-ambient PM2.5 exposure, J Hazard Mater, Volume 408, 15 April 2021, 124903 (Q1, IF=13.6)
6.X Shi, Y Zheng, H Cui, Y Zhang, M Jiang*, Exposure to outdoor and indoor air pollution and risk of overweight and obesity across different life periods: A review, Ecotoxicol Environ Saf, 242, 113893 (Q2, IF=6.8)
7.Jiang M, Li D, Piao J, Li J, Sun H, Chen L, Chen S, Pi J, Zhang R, Chen R, Leng S, Chen W, Zheng Y*, Real-ambient exposure to air pollution exaggerates excessive growth of adipose tissue modulated by Nrf2 signal. Sci Total Environ, 2020. 730: p. 138652 (Q1, IF=9.8)
8.Jiang M, Ye J, Wang X, Li N, Wang Y*, Shi Y*, Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals. Cell Biosci 2020;10 (Q2, IF=7.5)
9.Jiang M, Zheng C, Shou P, Li N, Cao G, Chen Q, Xu C, Du L, Yang Q, Cao J, Han Y, Li F, Cao W, Liu F, Rabson AB, Roberts AI, Xie W, Wang Y*, Shi Y*. SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation. Cell Rep 2016 07 19;16(3) (Q1, IF=8.8)
10.Jiang M, Gao T, Liu Y, Cao X, Li Y, Li J, Liu Y, Piao J*. CD14 dictates differential activation of mesenchymal stromal cells through AKT, NF-κB and P38 signals, Biosci. Rep. 2019 07 31;39(7)
三、主要科研项目
1.国家自然基金面上项目,82073597,拟杆菌和梭菌在DEE暴露致气道重塑中的作用及胞外囊泡(EVs)的调控机制研究,2021/01-2024/12,57万,在研,主持
2.国家自然基金青年项目,81702775,蛋白酪氨酸磷酸酶SHP1对间充质干细胞免疫调节特性的作用及其机制研究,2018/01-2020/12,19万,结题,主持
3.蛋白酪氨酸磷酸酶SHP1调控间充质干细胞免疫调节特性的机制研究,山东省自然科学基金,ZR2017BC00
4,2017-08至2019-12,10万,结题,主持4.PM2.5致脂肪组织增多的机制及Nrf2的调控作用研究,中国博士后科学基金面上项目,2018M630759,201807-201912,8万,结题,主持
5.磷酸酶PTP6对间充质干细胞免疫调节特性的作用及其机制研究,青岛市博士后应用研究项目,201801-201912,5万,结题,主持
四、联系方式
menghuidream@163.com