李传海，博士，助理教授，硕士生导师，青岛大学青年卓越人才。2019年6月毕业于中国科学院生态环境研究中心，获得环境科学博士学位。2019年8月入职青岛大学，从事新型环境污染物分子毒理机制的研究。迄今发表研究论文21篇，其中SCI收录论文18篇。
一、主要研究方向
1. 新型持久性有机污染物的毒性作用机制
2. 大气颗粒物致毒机制
二、代表性科研成果
第一作者论文：
1. Chuan-Hai Li, Ya-Li Shi, Min-Jie Li, Liang-Hong Guo, Ya-Qi Cai. Receptor-Bound Perfluoroalkyl Carboxylic Acids Dictate Their Activity on Human and Mouse Peroxisome Proliferator-Activated Receptor γ [J]. Environmental science & technology, 2020, 54 (15), 9529-9536. （IF 9.028）
2. Chuan-Hai Li, Xiao-Min Ren, Liang-Hong Guo. Adipogenic Activity of Oligomeric Hexafluoropropylene Oxide (Perfluorooctanoic Acid Alternative) through Peroxisome Proliferator-Activated Receptor γ Pathway [J]. Environmental science & technology, 2019, 53 (6), 3287-3295. （IF 9.028）
3. Chuan-Hai Li, Xiao-Min Ren, Lin-Ying Cao, Wei-Ping Qin, Liang-Hong Guo. Investigation of binding and activity of perfluoroalkyl substances to human peroxisome proliferator-activated receptor β/δ [J]. Environmental Science: Processes & Impacts, 2019, 21(11): 1908-1914. （IF 4.238）
4. Chuan-Hai Li, Xiao-Min Ren, Ting Ruan, Lin-Ying Cao, Yan Xin, Liang-Hong Guo, and Guibin Jiang. Chlorinated polyfluorinated ether sulfonates exhibit higher activity toward peroxisome proliferator-activated receptors signaling pathways than perfluorooctanesulfonate [J]. Environmental science & technology, 2018, 52 (5), 3232–3239. （IF 9.028）
5. Yun Wu#, Chuan-Hai Li#, Juan Zhao, Yong-Liang Xiao, Hui Cao. Metaproteome of the microbial community in paddy soil after long-term treatment with mineral and organic fertilizers [J]. Israel Journal of Ecology & Evolution, 2016,04: 1565-9801. (#equal contribution)
参与发表论文：
1. Lin Xu, Qianwen Zhao, Daochuan Li, Jiao Luo, Wanli Ma, Yuan Jin, Chuanhai Li, Jing Chen, Kunming Zhao, Yuxin Zheng, Dianke Yu. MicroRNA-760 resists ambient PM 2.5-induced apoptosis in human bronchial epithelial cells through elevating heme-oxygenase 1 expression [J]. Environmental pollution, 2021.
2. Jiao Luo, Mengyue Xie, Yufei Hou, Wanli Ma, Yuan Jin, Jing Chen, Chuanhai Li, Kunming Zhao, Ningning Chen, Lin Xu, Yanan Ji, Qianqian Zhang, Yuxin Zheng, Dianke Yu. A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease [J]. Biochemical pharmacology, 2021, 188, 114582.
3. Jiao Luo, Yufei Hou, Wanli Ma, Mengyue Xie, Yuan Jin, Lin Xu, Chuanhai Li, Ying Wang, Jing Chen, Wendi Chen, Yuxin Zheng, Dianke Yu. A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells [J]. Biochemical pharmacology. 2021, 114458.
4. Yuan Jin, Meiyao Feng, Wanli Ma, Yanhong Wei, Guangshuai Qi, Jiao Luo, Lin Xu, Xinmei Li, Chuanhai Li, Ying Wang, Daochuan Li, Jing Chen, Yanjie Zhao, Yufei Hou, Qianwen Zhao, Lidan Jiang, Mengyue Xie, Yuxin Zheng, Dianke Yu. A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study [J]. Environmental pollution. 2021, 268, 115733.
5. Lin Xu, Qianwen Zhao, Jiao Luo, Wanli Ma, Yuan Jin, Chuanhai Li, Yufei Hou, Meiyao Feng, Ying Wang, Jing Chen, Jinquan Zhao, Yuxin Zheng, Dianke Yu. Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity [J]. Ecotoxicology and environmental safety, 2020, 205, 111166.
6. Xubing Wang, Yanjie Zhao, Jiao Luo, Lin Xu, Xinmei Li, Yuan Jin, Chuanhai Li, Meiyao Feng, Ying Wang, Jing Chen, Yufei Hou, Qianwen Zhao, Jinquan Zhao, Baitang Ning, Yuxin Zheng, Dianke Yu. MicroRNA hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the Ethanol-Acetaldehyde-Acetate Metabolic Pathway [J]. Molecular pharmacology. 2020, 98(2), 120–129.
7. Weiping Qin, Linying Cao, Chuanhai Li, Lianghong Guo, John K Colbourne, Xiaomin Ren. Perfluoroalkyl Substances Stimulate Insulin Secretion by Islet β Cells via G Protein-Coupled Receptor 40 [J]. Environmental Science & Technology, 2020, 54(6): 3428-3436.
8. Xiao-Min Ren, Chuan-Hai Li, Jian-Qing Zhang, Liang-Hong Guo. Binding and activity of sulfated metabolites of lower-chlorinated polychlorinated biphenyls towards thyroid hormone receptor alpha [J]. Ecotoxicology and environmental safety, 2019, 180: 686-692.
9. Zhen-dong Sun, Xiao-Xi Yang, Qian-S Liu, Chuan-Hai Li, Qun-Fang Zhou, Heidelore Fiedler, Chun-Yang Liao, Jian-Qing Zhang, Gui-Bin Jiang. Butylated Hydroxyanisole Isomers Induce Distinct Adipogenesis in 3T3-L1 Cells [J]. Journal of hazardous materials, 2019: 120794.
10. Wei-Ping Qin, Chuan-Hai Li, Liang-Hong Guo, Xiao-Min Ren, Jian-Qing Zhang. Binding and activity of polybrominated diphenyl ether sulfates to thyroid hormone transport proteins and nuclear receptors[J]. Environmental Science: Processes & Impacts, 2019, 21(6): 950-956.
11. Lin-Ying Cao, Xiao-Min Ren, Chuan-Hai Li, Liang-Hong Guo. Organophosphate esters bind to and inhibit estrogen-related receptor γ in cells [J]. Environmental science & technology letters, 2018, 5 (2), 68–73.
12. Yan Xin, Xiao-Min Ren, Ting Ruan, Chuan-Hai Li, Liang-Hong Guo, Guibin Jiang. Chlorinated polyfluoroalkylether sulfonates exhibit similar binding potency and activity to thyroid hormone transport proteins and nuclear receptors as perfluorooctanesulfonate [J]. Environmental science & technology, 2018, 52 (16), 9412–9418.
13. Lin-Ying Cao, Xiao-Min Ren, Chuan-Hai Li, Jing Zhang, Wei-Ping Qin, Yu Yang, Bin Wan, Liang-Hong Guo. Bisphenol AF and bisphenol B exert higher estrogenic effects than bisphenol A via G protein-coupled estrogen receptor pathway [J]. Environmental science & technology, 2017, 51 (19), 11423–11430.
14. Yin-Feng Zhang, Xiao-Min Ren, Yuan-Yuan Li, Xiao-Fang Yao, Chuan-Hai Li, Zhan-Fen Qin, Liang-Hong Guo. Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo [J]. Environmental pollution, 2017, 237, 1072–1079.
三、主持的科研项目
1. 国家自然科学基金青年基金，82103875，PPARγ介导的miR-378c在F-53B诱导肝脂代谢紊乱中的调控机制研究，2022/01-2024/12，24.00万元，项目负责人。
2. 山东省青年基金项目，RZ2100001120，hsa-miR-532调控PFOA新型替代品六氟环氧丙烷低聚物致肝脂代谢紊乱机制的研究，2021/01-2023/12，14.00万元，项目负责人。
联系方式
E-mail：chli@qdu.edu.cn
