赵坤明，1992年生。2020年6月毕业于哈尔滨工业大学，获得生物医学工程博士学位。2020年入职必赢线路检测中心，助理教授，青年卓越人才，硕士生导师。
一、主要研究方向
化学致癌进程的分子机制研究（功能性蛋白质及表观遗传调控方向）
二、代表性科研成果
1. Kunming Zhao#, Xinyi Wang#, Yaqiong Jin#, Xiaoxiao Zhu, Tao Zhou, Yongbo Yu, Xiaoying Ji, Yan Chang, Jiao Luo, Xin Ni*, Yongli Guo*, Dianke Yu*. LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma. Cell Death & Disease. 2024 Jan 4;15(1):5. (中科院一区，IF: 9.0)
2. Kunming Zhao#, Xingwen Wang#, Dong Zhao#, Qingyu Lin, Yi Zhang, Ying Hu*. lncRNA HITT Inhibits Lactate Production by Repressing PKM2 Oligomerization to Reduce Tumor Growth and Macrophage Polarization. Research, 2022: 9854904. (中科院一区，IF: 11.0)
3. Kunming Zhao, Xingwen Wang, Ying Hu*. Identification of lncRNA-Protein Interactions by CLIP and RNA Pull-Down Assays. Long Non-Coding RNAs in Cancer, Humana Press, 2021.
4. Kunming Zhao, Ying Hu*. Microbiome harbored within tumors: a new chance to revisit our understanding of cancer pathogenesis and treatment. Signal Transduction and Targeted Therapy, 2020, 5(1): 136-138. (中科院一区，IF: 18.2)
5. Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu*. A long non-coding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers. Plos Biology, 2020, 18(3): e3000666. (中科院一区，IF: 8.0)
6. Kunming Zhao, Miao Yu, Yifu Zhu, Dong Liu, Qiong Wu, Ying Hu*. EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy. Cell Death & Disease, 2017, 8(6): e2869. (中科院二区，IF: 5.6)
7. Wenjie Ge#, Kunming Zhao#, Xingwen Wang, Huayi Li, Miao Yu, Mengmeng He, Xuting Xue, Yifu Zhu, Cheng Zhang, Yiwei Cheng, Shijian Jiang, Ying Hu*. iASPP is an antioxidative factor and drives cancer growth and drug resistance by competing with Nrf2 for Keap1 binding. Cancer Cell, 2017, 32(5): 561-573. (Featured article, 中科院一区，IF: 31.7)
8. Xingwen Wang, Li Li, Kunming Zhao, Qingyu Lin, Xuting Xue, Wenjie Ge, Hongjuan He, Dong Liu, Qiong Wu, Ying Hu*. A novel LncRNA HITT forms a regulatory loop with HIF-1α to modulate angiogenesis and tumor growth. Cell Death & Differentiation, 2020, 27(4):1431-1446. (中科院一区，IF: 15.8)
9. Huayi Li#, Wenxin Zhang#, Kunming Zhao, Dong Zhao, Shanliang Zheng, Ying Hu*. A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. Journal of Biological Chemistry, 2020, 295(12):4049-4063. (中科院二区，IF: 5.2)
三、主要科研项目
1. 国家自然科学基金委员会，青年项目，82204087，tRNA衍生片段tRF-Gly-GCC调控支链氨基酸关键代谢酶在亚硝胺诱发肝癌中的作用机制研究，2023-01至2025-12，30万元，在研，主持；
2. 山东省自然科学基金，青年项目，ZR2021QH278，LncRNA ZNF674-AS1调控神经母细胞瘤发生发展的机制研究，2022-01至2024-12，15万元，在研，主持。
四、联系方式
E-mail：zkm6711217@163.com（常用邮箱）或zhaokunming@qdu.edu.cn
