沈晓丽，女，1977年生，理学博士，美国普渡大学博士后，教授，博士生导师。中国卫生信息与健康医疗大数据学会卫生统计教育专委会委员，山东省预防医学会卫生统计分会委员，山东省医学会公共卫生分会委员，山东省医学会医学教育分会委员。
主要从事流行病与卫生统计学的科研与教学工作。承担国家自然科学面上项目1项，基金青年基金1项，山东省自然科学基金面上项目1项，中国博士后科学基金面上项目1项。共发表SCI文章24篇，其中第一作者6篇，通讯作者11篇。获山东省科技进步奖二等奖一项（第6位），青岛市科技进步一等奖1项（第5位）。指导学生获山东省优秀学士学位论文1项,第十七届“挑战杯”青岛大学大学生课外学术科技作品竞赛一等奖1项。
一、主要研究方向
1.金属元素与神经退行性疾病
（1）利用生态流行病学的方法证明了中国大陆地区土壤中金属元素含量与阿尔茨海默病死亡率之间的具有正相关关系，阿尔茨海默病死亡率随着土壤中铁、铜、砷含量增加而升高，为铁、铜、砷参与阿尔茨海默病的发病提供了新的证据。
（2）利用病例-对照研究发现帕金森病人和健康对照血液中铁元素含量无差异，脑脊液铁含量下降。
（3）采用动物实验阐明铅对血-脑脊液屏障转运Beta-淀粉样蛋白的影响及RAGE、LRP1蛋白在其中的作用，为铅和阿尔茨海默样病变之间的关系提供新的证据。
2.脑肠肽与神经退行性疾病
在动物和细胞水平上阐明了新发现的脑肠肽nesfatin-1通过C-Raf-ERK信号通路，拮抗MPTP和MPP+诱导的多巴胺能神经元损伤，保护多巴胺能神经元功能；同时证明脑区nesfatin-1含量降低能够诱导黑质纹状体系统损伤，提示nesfatin-1在维持中脑黑质纹状体系统生理功能中发挥作用。
二、代表性科研成果
1）学术论文
通讯作者
1.Cui YX, Zhang F, Wang H, Wu J, Zhang DF, Xing YF, Shen XL*. Children who appeared or remained overweight or obese predict a higher follow-up blood pressure and higher risk of hypertension: a 6-year longitudinal study in Yantai, China. Hypertens Res. 2023 Apr 24. doi: 10.1038/s41440-023-01286-y. 中科院二区
2.Wang H, Cui YX, Zhang F, Song RH, Zhao LZ, Han MM, Shen XL*. Association between urinary phthalate metabolites and hyperuricemia in US adults. Environ Sci Pollut Res Int . 2023 Jan 12.
3.Zhao LZ, Zhan RQ, Wang XT, Song RH, Han MM, Shen XL*. Correlation between dietary theobromine intake and low cognitive performance in older adults in the United States: A cross-sectional study based on the National Health and Nutrition Examination Survey. Asia Pac J Clin Nutr. 2023;32(1):120-132.
4.Zhang F, Huai RH, Jia FJ, Cui YX, Wang H, Shen XL*. Association between mixed dietary B vitamin intake and insulin resistance in US middle-aged and older adults without diabetes: The Bayesian kernel machine regression approach. Asia Pac J Clin Nutr. 2022;31(4):768-779.
5.Cui YX, Zhang F, Wang H, Zhao LZ, Song RH, Han MM, Shen XL*. Temporal Associations between Tri-Ponderal Mass Index and Blood Pressure in Chinese Children: A Cross-Lag Analysis, Nutrients, 2022 Apr, 14(9): 1783. doi: 10.3390/nu14091783. 中科院二区
6.Zhang F, Wang H, Cui YX, Zhao LZ, Song RH, Han MM, Wang WJ, Zhang DF, Shen XL*. Association between mixed dioxin exposure and hyperuricemia in U.S. adults: A comparison of three statistical models. Chemosphere 2022:135134. JCR1区，top期刊
7.Wang XX, Li XL, Xing YF, Wang WJ, Li SY, Zhang DF, Zheng W, Shen XL*.Threshold effects of total copper intake on cognitive function in US older adults and the moderating effect of fat and saturated fatty acid intake. Academy of nutrition and dietetics. June 1,2021. 中科院二区
8.Gao Y, Shen L, Zhan RQ, Wang XX, Chen HH, Shen XL*. Association of lung function with functional limitation in older adults: A cross-sectional study. PLoS One. 2021;16(6):e0253606.
9.Chen HH, Li XL, Ma H, Zheng W, Shen XL*. Reduction in nesfatin-1 levels in the cerebrospinal fluid and increased nigrostriatal degeneration following ventricular administration of anti-nesfatin-1 antibody in mice. Frontiers in neuroscience. 2021,15:621173. 中科院二区
10.Li XL, Zhan RQ, Zheng W, Jiang H, Zhang DF, Shen XL*. Positive association between soil arsenic concentration and mortality from alzheimer’s disease in mainland China. J Trace Elem Med Biol. 2020 Jan 8;59:126452.
11.Shen XL*,Yang HZ , Zhang DF, Jiang H. Meta-analysis: Association of Helicobacter pylori infection with Parkinson's diseases, Helicobacter, 2017 Oct, 22(5). 中科院二区
第一作者
1.Shen XL, Xia L, Liu LQ, Jiang H, Shannahan J, Du YS, Zheng W*. Altered clearance of beta-amyloid from the cerebrospinal fluid following subchronic lead exposure in rats: Roles of RAGE and LRP1 in the choroid plexus. J Trace Elem Med Biol. 2020 Mar 8;61:126520.
2.Shen X，Yang HZ，Zhang DF，Jiang H*，Iron concentration does not differ in blood but tends to decrease in cerebrospinal fluid in Parkinson’s disease，Frontiers in neuroscience，2019,13:919. 中科院二区
3.Shen X，Song N，Du XX，Li Y，Xie JX，Jiang H*，Nesfatin-1 protects dopaminergic neurons against MPP+/MPTP-induced neurotoxicity through the C-Raf-ERK1/2-dependent anti-apoptotic pathway，Sci Rep，2017 Jan 20;7:40961.
4.Shen X, Wu Y, Zhang D*. Nighttime sleep duration, 24-hour sleep duration and risk of all-cause mortality among adults: a meta-analysis of prospective cohort studies. Sci Rep, 2016, Feb, 6:21480.
5.Shen X, Yu J, Zhang D, Xie J, Jiang H*. Positive relationship between mortality from Alzheimer’s disease and soil metal concentration in mainland China. J Alzheimers Dis, 2014, 42（3）:893-900.中科院二区
6.Shen X#, Jia F#, Song N, Xie J, Jiang H*. Protection of MES23.5 dopaminergic cells by obestatin is mediated by proliferative rather than anti-apoptotic action. Neurosci Bull, 2014, 30(1):118-124.
其他作者
1.Tan Z, Xu H, Shen X, Jiang H. Nesfatin-1 antagonized rotenone-induced neurotoxicity in MES23.5 dopaminergic cells. Peptides, 2015 ,69:109-114.
2.Yu J, Xu H, Shen X, Jiang H. Ghrelin protects MES23.5 cells against rotenone via inhibiting mitochondrial dysfunction and apoptosis. Neuropeptides, 2015, S0143-4179(15): 00100-00106.
3.Wang L, Shen X, Wu Y, Zhang D. Coffee and caffeine consumption and depression: A meta-analysis of observational studies. Aust N Z J Psychiatry, 2016 , 50(3): 228-242.
4.Ma Y, Shen X, Zhang D. The Relationship between Serum Zinc Level and Preeclampsia: A Meta-Analysis. Nutrients, 2015,7(9):7806-7820.
5.Zhang D, Shen X, Qi X. Resting heart rate and all-cause and cardiovascular mortality in the general population: a meta-analysis. CMAJ. 2016 Feb 16;188(3):E53-63.
6.Zhan R, Shen X, Ma Z, Li S, Liang J,Zhang W. Dietary vitamin D intake and risk of non-small cell lung cancer: a matched case-control study. Transl Cancer Res. 2016;5(4):470-475. doi: 10.21037/tcr.2016.07.19
7.Song N, Wang W, Jia F, Du X, Xie A, He Q, Shen X, Zhang J, Rogers JT, Xie J, Jiang H. Assessments of plasma ghrelin levels in the early stages of Parkinson’s disease. Mov Disord. 2017 Oct; 32(10):1487-1491.
三、主要科研项目
1．国家自然科学基金面上项目，82171570， Nesfatin-1基于脑肠轴参与帕金森病发病的机制研究，54万，2022.01—2025.12，第1位。
2.国家自然科学基金青年基金，81701377，黑皮质素4受体激活的C-Raf/ERK/CREB通路在nesfatin-1保护黑质多巴胺能神经元中的作用研究，20万，2018.01—2020.12，第1位。
3．山东省自然科学基金面上项目，ZR2016HM11，Nesfatin-1结合黑皮质素4受体激活Ras/Erk/CREB信号通路保护黑质多巴胺能神经元的作用研究，18万，2016.11—2019.6，第1位。
4．中国博士后科学基金面上项目，2016M592145，脑肠肽nesfatin-1对帕金森病模型的保护作用及机制研究，2016.01-2017.12， 5万元，在研，第1位。
5.青岛市博士后应用研究项目资助，2015158，CaMKII/IV/CREB/Bcl-2信号通路激活在nesfatin-1保护多巴胺能神经元中的作用研究，2016/01-2016/12、5万元、在研、第1位。
四、获奖
1、脑肠肽ghrelin与帕金森病发生发展的关系及在帕金森病早期诊断中的应用，青岛市科学技术奖，科技进步奖一等奖，第5位，2019年年7月。
2、脑肠肽ghrelin与帕金森病发生发展的关系及在帕金森病早期诊断中的应用，山东省科技奖，科学科技进步奖二等奖，第6位，2020年12月，山东省人民政府。
3、唐山市抗击非典嘉奖，2004年。
五、联系方式
办公电话：0532-82991712
E-mail：shenxiaoli@qdu.edu.cn；shenxiaoli2000@163.com
